Some patients may experience benefit with 3 injections of HYALGAN®*

HYALGAN® 3-injection regimen vs placebo at day 60 6


Study design

Double-blind, placebo- and arthrocentesis-controlled trial; patients (N=100) were randomized into 5 groups (saline-control weekly × 5, plus arthrocentesis at baseline; arthrocentesis weekly × 5; HYALGAN® 20 mg weekly × 1, plus arthrocentesis weekly × 5; HYALGAN® 20 mg weekly × 3, plus arthrocentesis at baseline and days 21 and 28; HYALGAN® 20 mg weekly × 5, plus arthrocentesis at baseline). 6

HYALGAN® 3-injection regimen vs placebo at day 60 7


Study design

Placebo-controlled, single-blind, parallel study (N=55) comparing 20 mg HYALGAN® weekly × 3, 40 mg HYALGAN® weekly × 3, and 2 mL saline weekly × 3. 7

Note: 20 mg is the approved dose.

HYALGAN® 3-injection regimen and exercise at day 60


Defy the Pain
  • Adding home exercise may provide faster pain relief than HYALGAN® alone 16
  • May help to forestall knee surgery 17
Study design

Single-blinded, parallel-design, 1-year clinical study with sequential enrollment of (N=60) to assess efficacy and safety of intra-articular (i.a.) HYALGAN® with or without a home exercise program for the management of OA knee pain. 16

*p>0.01 comparing 3-HYL+HEP with 3-HYL or 5-HYL
†p>0.05 comparing 3-HYL+HEP and 5-HYL with 3-HYL
‡p>0.05 comparing 3-HYL with 5-HYL
* Some patients may experience benefit with 3 injections given at weekly intervals (one injection per week for three weeks). This has been noted in studies reported in the literature in which patients treated with 3 injections were followed for 60 days.
† As measured using 100-mm VAS.