Significant and long-lasting pain relief with 5-injection regimen

In the randomized controlled hyaluronate study conducted in the US (N=495) among patients with osteoarthritis (OA) of the knee…

HYALGAN® demonstrated long-lasting efficacy with a 5-injection regimen vs placebo 1


US pivotal trial demonstrates long-lasting efficacy as effective as daily naproxen

One 5-injection cycle of HYALGAN® provided 6 months of pain relief equivalent to 364 doses of naproxen (500 mg bid), with fewer adverse events 1

Study design

6-month, double-blind, placebo-controlled, US multicenter study (N=495) in patients ≥40 years with Kellgren grade 2 or 3 OA of the knee. The study compared intra-articular (i.a.) HYALGAN® 20 mg/wk × 5 with i.a. saline and 500 mg bid naproxen groups. All patients were allowed up to 4,000 mg/d for rescue analgesia (acetaminophen) as needed for pain. 1

* Mean pain score for completed patients during a 50-foot walk recorded on a 100-mm visual analog scale (VAS) adjusted for baseline severity (HYALGAN®, 54 mm; placebo, 55 mm).
† At week 26, HYALGAN® was better than saline control for the mean difference in the pain scale adjusted for baseline severity.